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Heterochromatin-Protein 1 – Wikipedia Zum Inhalt springen

Heterochromatin-Protein 1

aus Wikipedia, der freien Enzyklopädie
(Weitergeleitet von CBX1)
{{#if: | {{#if: 2fmm| {{#if:1551| {{#if: 118 aa; 13,73 kDa | {{#if: Homodimer | {{#if: | {{#if: (185 aa; 21,4 kDa) | {{#if: HP1α, HP1β, HP1γ | {{#if: CBX1CBX, HP1604511105369 | {{#if: CBX1CBX, HP1 | {{#if: 604511105369 | {{#if: | {{#if:| {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: Eukaryoten{{#if: | {{#ifeq: HBG351949 | NV ||1}}|}}| {{#if: | {{#ifeq: HBG351949 | NV || | style="background:#C3FDB8; color:#000000;" | Homologie-Familie {{#if: Eukaryoten | | style="background:#C3FDB8; color:#000000;" | Übergeordnetes Taxon {{#if: | | style="background:#C3FDB8; color:#000000;" | Ausnahmen {{#if: {{#if: Maus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe {{#if: ENSG00000108468ENSMUSG00000018666
{{#if: Chromobox-Homolog 1 | Chromobox-Homolog 1 | Heterochromatin-Protein 1 }}
Heterochromatin-Protein 1 }}
CBX1 Dimer (gelb) mit EMSY, nach PDB 2FMM
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Andere Namen

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Vorhandene Strukturdaten: 2fmm }}

Eigenschaften des menschlichen Proteins

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Masse/Länge Primärstruktur 118 aa; 13,73 kDa

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Sekundär- bis Quartärstruktur Homodimer

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Kofaktor

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Präkursor (185 aa; 21,4 kDa)

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Isoformen HP1α, HP1β, HP1γ

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Bezeichner
{{#if:CBX, HP1 | Gen-Namen | Gen-Name}} | Gen-Name(n) }} {{#if:1551 | CBX1 | CBX1}}{{#if:CBX, HP1 |, CBX, HP1}} }}
Externe IDs

{{#if: |

0 | }} - = – valid|1|2=/^[1-9]%d?%d?%d?%d?%d?%d?%d?%d?$/ 0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}} template= Vorlage:PubChem format=

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 }}

}}

Arzneistoffangaben
ATC-Code 
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 {{#if:|
DrugBank [1] 
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 {{#if:|
Wirkstoffklasse 
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}}

Transporter-Klassifikation
TCDB {{{TCDB}}} 
 {{#if: |
Bezeichnung {{{TranspText}}} 
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}}

{{#if:|Inhibitorklassifikation|{{#if:|Enzymklassifikationen|Enzymklassifikation}}}}
EC, Kategorie {{#if:| [2]}}{{#if: |, [[]]}} }}
MEROPS {{{Peptidase_fam}}}}}
MEROPS {{{Inhibitor_fam}}}}}
Reaktionsart 
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Substrat 
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Produkte 
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}}

Vorkommen
{{#if: HBG351949|Hovergen}}] HBG351949|Hovergen}}]}} }} }}
Eukaryoten }}
}}

}}

Mensch Maus
Entrez 
 {{ #if: 10951
10951 }} 
 {{ #if:
[3] }}
style="background:#C3FDB8; color:#202122;" | Ensembl 
    {{ #if: ENSG00000108468
ENSG00000108468 }} 
    {{ #if: ENSMUSG00000018666
ENSMUSG00000018666 }}

} 

 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: P83916
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P83916}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: P83917
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P83917}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_006807NM_007622
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_006807
         | | NM_006807
         | |  }}
      {{ #if: NM_007622
         | | NM_007622
         | |  }}
    |}}
 |-
 {{#if: NP_006798NP_031648
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_006798
         | | NP_006798
         | |  }}
      {{ #if: NP_031648
         | | NP_031648
         | |  }}
    |}}
 |-
 {{#if: 174350241343533559119665045096669954
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 17 
        | {{#if: 43502413 
            | {{#if: 43533559 
                | |  #if:  |?db=|}}&position=chr17:43502413-43533559 Chr 17: {{#expr: 43502413 / 1000000 round 2}} – {{#expr: 43533559 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 11 
        | {{#if: 96650450 
            | {{#if: 96669954 
                | |  #if:  |?db=|}}&position=chr11:96650450-96669954 Chr 11: {{#expr: 96650450 / 1000000 round 2}} – {{#expr: 96669954 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 10951
    | | 10951
    | |  }}
 {{ #if: 
    | | [4]
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 10951 

 {{#if: ENSG00000108468
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000108468 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P83916}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_006807
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_006807 }} 

 {{#if: NP_006798
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_006798 }} 

 {{#if: 17 
   | {{#if: 43502413 
       | {{#if: 43533559 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: |?db=|}}&position=chr17:43502413-43533559 Chr 17: {{#expr: 43502413 / 1000000 round 2}} – {{#expr: 43533559 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 10951 }} {{#if: Maus 

    | {{#if: ENSMUSG00000018666NM_007622NP_031648119665045096669954P83917 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: ENSMUSG00000018666NM_007622NP_031648119665045096669954P83917 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} | {{#if: Maus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe 

 |-
 | style="background:#C3FDB8; color:#202122;" |
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Mensch
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Maus
 |-
 | style="background:#C3FDB8; color:#202122;" | Entrez
 {{ #if: 10951
    | | 10951
    | |  }}
 {{ #if: 
    | | [5]
    | |  }}
 |-
 {{#if: ENSG00000108468ENSMUSG00000018666
    | | style="background:#C3FDB8; color:#202122;" | Ensembl
    {{ #if: ENSG00000108468
       || ENSG00000108468
       ||  }}
    {{ #if: ENSMUSG00000018666
       || ENSMUSG00000018666
       ||  }}
  |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: P83916
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P83916}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: P83917
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P83917}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_006807NM_007622
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_006807
         | | NM_006807
         | |  }}
      {{ #if: NM_007622
         | | NM_007622
         | |  }}
    |}}
 |-
 {{#if: NP_006798NP_031648
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_006798
         | | NP_006798
         | |  }}
      {{ #if: NP_031648
         | | NP_031648
         | |  }}
    |}}
 |-
 {{#if: 174350241343533559119665045096669954
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 17 
        | {{#if: 43502413 
            | {{#if: 43533559 
                | |  #if:  |?db=|}}&position=chr17:43502413-43533559 Chr 17: {{#expr: 43502413 / 1000000 round 2}} – {{#expr: 43533559 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 11 
        | {{#if: 96650450 
            | {{#if: 96669954 
                | |  #if:  |?db=|}}&position=chr11:96650450-96669954 Chr 11: {{#expr: 96650450 / 1000000 round 2}} – {{#expr: 96669954 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 10951
    | | 10951
    | |  }}
 {{ #if: 
    | | [6]
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 10951 

 {{#if: ENSG00000108468
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000108468 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P83916}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_006807
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_006807 }} 

 {{#if: NP_006798
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_006798 }} 

 {{#if: 17 
   | {{#if: 43502413 
       | {{#if: 43533559 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: |?db=|}}&position=chr17:43502413-43533559 Chr 17: {{#expr: 43502413 / 1000000 round 2}} – {{#expr: 43533559 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 10951 }} {{#if: Maus 

    | {{#if: ENSMUSG00000018666NM_007622NP_031648119665045096669954P83917 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: ENSMUSG00000018666NM_007622NP_031648119665045096669954P83917 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} }}

|}{{#if:CBX1+EMSY 2FMM.png||}}

Bei der Familie der Heterochromatin-Proteine 1 (HP1) (auch „Chromobox-Homolog“, CBX) handelt es sich um hochkonservierte Adaptermoleküle, die eine Vielzahl essentieller Funktionen im Zellkern übernehmen. Hierzu zählen die epigenetische Genregulation, die Aufrechterhaltung der Genomstabilität und die Ausbildung einer „Plattform“ für den Wiederaufbau der Zellkerne in der Endphase der Mitose. Erstmals beschrieben wurde es 1986 von Sarah Elgin in Drosophila melanogaster<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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  }}</ref> als ein Protein, welches als mutierte Form mit der Unterdrückung der Positionseffekt-Variegation verbunden ist. 1991 wurde von Prim Singh nachgewiesen, dass HP1 ein hochkonserviertes Protein des Heterochromatin ist und eine fundamentale Rolle in der epigenetischen Regulation spielt.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 
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Isoformen

In Säugetieren gibt es die Isoformen HP1α, HP1β und HP1γ.

HP1β

HP1β interagiert direkt mit der Histon-Methyltransferase Suv(3)9h1 und ist eine Komponente von perizentrischen und telomeren Heterochromatin.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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    | Vorlage:Cite book/Meldung
  }}</ref><ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 
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  }}{{#invoke:TemplatePar|check
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     || Vorlage:Cite book/Meldung
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  }}</ref> HP1β kann Dosis-abhängig Gene auf perizentrischem Heterochromatin stilllegen.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 
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     || Vorlage:Cite book/Meldung
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     | Vorlage:Cite book/Meldung
  }}Vorlage:Cite book/Meldung2{{#ifexpr: 0{{#ifeq:^^|^^||+1}}{{#ifeq:^^|^^||+1}}{{#ifeq:Festenstein R, Sharghi-Namini S, Fox M, et al.|^^||+1}}{{#ifeq:^^|^^||+1}} > 1
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  }}</ref> Der Prozess des Stilllegens wird durch die Interaktion der HP1β-Chromodomäne und die Histonmodifikation Me(3)K9H3 vermittelt.

Einzelnachweise

<references />

Literatur

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Weblinks

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