Coproporphyrinogen-Oxidase

{{#if: | {{#if: 2aex| {{#if:2321| {{#if: 344 Aminosäuren | {{#if: Homodimer | {{#if: | {{#if: | {{#if: | {{#if: CPOXCPO, CPX, HCPP36551612732104841 | {{#if: CPOXCPO, CPX, HCP | {{#if: P36551612732104841 | {{#if: | {{#if:| {{#if: | {{#if: 1.3.3.3OxidoreduktaseOxidative DecarboxylierungCoproporphyrinogen III + O₂ + 2 H⁺Protoporphyrinogen IX + 2 CO₂ + 2 H₂O | {{#if: 1.3.3.3Oxidoreduktase| {{#if: | {{#if: | {{#if: Oxidative Decarboxylierung| {{#if: Coproporphyrinogen III + O₂ + 2 H⁺| {{#if: Protoporphyrinogen IX + 2 CO₂ + 2 H₂O| {{#if: {{#if: P36551 | {{#ifeq: CPOX | NV ||1}}|}}| {{#if: P36551 | {{#ifeq: CPOX | NV || | style="background:#C3FDB8; color:#000000;" | Homologie-Familie {{#if: | | style="background:#C3FDB8; color:#000000;" | Übergeordnetes Taxon {{#if: | | style="background:#C3FDB8; color:#000000;" | Ausnahmen {{#if: {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe {{#if: ENSG00000080819ENSMUSG00000022742

{{#if: | | Coproporphyrinogen-Oxidase }}
Coproporphyrinogen-Oxidase }}
Andere Namen	{{{Andere Namen}}} }}
Vorhandene Strukturdaten: 2aex }}
Eigenschaften des menschlichen Proteins }}
Masse/Länge Primärstruktur	344 Aminosäuren }}
Sekundär- bis Quartärstruktur	Homodimer }}
Kofaktor	}}
Präkursor	}}
Isoformen	}}
Bezeichner
{{#if:CPO, CPX, HCP | Gen-Namen | Gen-Name}} | Gen-Name(n) }}	{{#if:2321 | CPOX | CPOX}}{{#if:CPO, CPX, HCP |, CPO, CPX, HCP}} }}
Externe IDs	{{#if: | GeneCards: Vorlage:GeneCards}}{{#if:612732 | OMIM: 612732}}{{#if:P36551| {{#if: | | UniProt }} {{#if:|{{{titel}}}|P36551}}{{#if:|Vorlage:Abrufdatum}}}}{{#if:104841 | MGI: 104841}}{{#if: | PubChem: {{#switch: {{{PubChem}}}		0 | }}	- = –	valid|1|2=/^[1-9]%d?%d?%d?%d?%d?%d?%d?%d?$/	0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}}	template= Vorlage:PubChem	format= }} }}{{#invoke:TemplatePar|check	all= 1=	opt= 2=	0 | Wikipedia:Vorlagenfehler/Vorlage:PubChem}}	template= Vorlage:PubChem	format= }}{{#if: {{#invoke:Wikidata|pageId}}||{{#ifeq: 0 | 0 | }} }}}}{{#if: | CAS-Nummer:  }}{{#if: | }} }} }}
Arzneistoffangaben
ATC-Code	}} {{#if:|
DrugBank	[1] }} {{#if:|
Wirkstoffklasse	}} }}
Transporter-Klassifikation
TCDB	[2] {{#if: |
Bezeichnung	}} }}
{{#if:|Inhibitorklassifikation|{{#if:|Enzymklassifikationen|Enzymklassifikation}}}}
EC, Kategorie	{{#if:1.3.3.3| 1.3.3.3}}{{#if: Oxidoreduktase|, Oxidoreduktase}} }}
MEROPS	[3]}}
MEROPS	[4]}}
Reaktionsart	Oxidative Decarboxylierung }}
Substrat	Coproporphyrinogen III + O2 + 2 H+ }}
Produkte	Protoporphyrinogen IX + 2 CO2 + 2 H2O }} }}
Vorkommen
{{#if:		CPOX|Hovergen}}]	CPOX|Hovergen}}]}} }} }}
}}
}} }}
	Mensch	Hausmaus
Entrez {{ #if: 1371	1371	}} {{ #if: 12892	12892	}}
style="background:#C3FDB8; color:#202122;" | Ensembl {{ #if: ENSG00000080819	ENSG00000080819	}} {{ #if: ENSMUSG00000022742	ENSMUSG00000022742	}}

}

 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: P36551
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P36551}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: P36552
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P36552}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_000097NM_007757
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_000097
         | | NM_000097
         | |  }}
      {{ #if: NM_007757
         | | NM_007757
         | |  }}
    |}}
 |-
 {{#if: NP_000088NP_031783
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_000088
         | | NP_000088
         | |  }}
      {{ #if: NP_031783
         | | NP_031783
         | |  }}
    |}}
 |-
 {{#if: 39852113298593723165867020858680391
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 3 
        | {{#if: 98521132 
            | {{#if: 98593723 
                | |  #if: hg38 |?db=hg38|}}&position=chr3:98521132-98593723 Chr 3: {{#expr: 98521132 / 1000000 round 2}} – {{#expr: 98593723 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 16 
        | {{#if: 58670208 
            | {{#if: 58680391 
                | |  #if: mm10 |?db=mm10|}}&position=chr16:58670208-58680391 Chr 16: {{#expr: 58670208 / 1000000 round 2}} – {{#expr: 58680391 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 1371
    | | 1371
    | |  }}
 {{ #if: 12892
    | | 12892
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 1371

 {{#if: ENSG00000080819
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000080819 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P36551}}{{#if:|Vorlage:Abrufdatum}}

 {{#if: NM_000097
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_000097 }}

 {{#if: NP_000088
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_000088 }}

 {{#if: 3 
   | {{#if: 98521132 
       | {{#if: 98593723 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: hg38 |?db=hg38|}}&position=chr3:98521132-98593723 Chr 3: {{#expr: 98521132 / 1000000 round 2}} – {{#expr: 98593723 / 1000000 round 2}} Mb

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 1371 }} {{#if: Hausmaus

    | {{#if: 12892ENSMUSG00000022742NM_007757NP_031783mm10165867020858680391P36552 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 12892ENSMUSG00000022742NM_007757NP_031783mm10165867020858680391P36552 
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        |}}

}}{{#invoke:TemplatePar|check |all= Spezies1= S1_EntrezGene= S1_Uniprot= |opt= Spezies2= S1_Ensembl= S1_RefseqmRNA= S1_RefseqProtein= S1_GenLoc_db= S1_GenLoc_chr= S1_GenLoc_start= S1_GenLoc_end= S2_EntrezGene= S2_Ensembl= S2_RefseqmRNA= S2_RefseqProtein= S2_GenLoc_db= S2_GenLoc_chr= S2_GenLoc_start= S2_GenLoc_end= S2_Uniprot= |cat= {{#ifeq: 0 | 0 |Wikipedia:Vorlagenfehler/Vorlage:Infobox Protein}} |template= Vorlage:Infobox Protein }} | {{#if: Hausmaus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe

 |-
 | style="background:#C3FDB8; color:#202122;" |
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Mensch
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Hausmaus
 |-
 | style="background:#C3FDB8; color:#202122;" | Entrez
 {{ #if: 1371
    | | 1371
    | |  }}
 {{ #if: 12892
    | | 12892
    | |  }}
 |-
 {{#if: ENSG00000080819ENSMUSG00000022742
    | | style="background:#C3FDB8; color:#202122;" | Ensembl
    {{ #if: ENSG00000080819
       || ENSG00000080819
       ||  }}
    {{ #if: ENSMUSG00000022742
       || ENSMUSG00000022742
       ||  }}
  |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: P36551
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P36551}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: P36552
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P36552}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_000097NM_007757
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_000097
         | | NM_000097
         | |  }}
      {{ #if: NM_007757
         | | NM_007757
         | |  }}
    |}}
 |-
 {{#if: NP_000088NP_031783
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_000088
         | | NP_000088
         | |  }}
      {{ #if: NP_031783
         | | NP_031783
         | |  }}
    |}}
 |-
 {{#if: 39852113298593723165867020858680391
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: 3 
        | {{#if: 98521132 
            | {{#if: 98593723 
                | |  #if: hg38 |?db=hg38|}}&position=chr3:98521132-98593723 Chr 3: {{#expr: 98521132 / 1000000 round 2}} – {{#expr: 98593723 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: 16 
        | {{#if: 58670208 
            | {{#if: 58680391 
                | |  #if: mm10 |?db=mm10|}}&position=chr16:58670208-58680391 Chr 16: {{#expr: 58670208 / 1000000 round 2}} – {{#expr: 58680391 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 1371
    | | 1371
    | |  }}
 {{ #if: 12892
    | | 12892
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 1371

 {{#if: ENSG00000080819
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000080819 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|P36551}}{{#if:|Vorlage:Abrufdatum}}

 {{#if: NM_000097
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_000097 }}

 {{#if: NP_000088
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_000088 }}

 {{#if: 3 
   | {{#if: 98521132 
       | {{#if: 98593723 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: hg38 |?db=hg38|}}&position=chr3:98521132-98593723 Chr 3: {{#expr: 98521132 / 1000000 round 2}} – {{#expr: 98593723 / 1000000 round 2}} Mb

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 1371 }} {{#if: Hausmaus

    | {{#if: 12892ENSMUSG00000022742NM_007757NP_031783mm10165867020858680391P36552 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 12892ENSMUSG00000022742NM_007757NP_031783mm10165867020858680391P36552 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}}{{#invoke:TemplatePar|check |all= Spezies1= S1_EntrezGene= S1_Uniprot= |opt= Spezies2= S1_Ensembl= S1_RefseqmRNA= S1_RefseqProtein= S1_GenLoc_db= S1_GenLoc_chr= S1_GenLoc_start= S1_GenLoc_end= S2_EntrezGene= S2_Ensembl= S2_RefseqmRNA= S2_RefseqProtein= S2_GenLoc_db= S2_GenLoc_chr= S2_GenLoc_start= S2_GenLoc_end= S2_Uniprot= |cat= {{#ifeq: 0 | 0 |Wikipedia:Vorlagenfehler/Vorlage:Infobox Protein}} |template= Vorlage:Infobox Protein }} }}

|}{{#if:Protein CPOX PDB 2aex.png||}}

{{#invoke:TemplatePar

|check

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Coproporphyrinogen-Oxidase (CPOX) ist das Enzym, das die Oxidation von Coproporphyrinogen III zu Protoporphyrinogen IX katalysiert, eine Teilreaktion bei der Biosynthese der Porphyrine, die in allen Lebewesen stattfindet. In Eukaryoten wird vorher das Substrat aus dem Zytosol in den Raum zwischen der inneren und äußeren Membran der Mitochondrien transportiert, der beteiligte Transporter ist noch unbekannt. Beim Menschen können Mutationen am CPOX-Gen zu CPOX-Mangel und damit zu hereditärer Koproporphyrie führen.<ref>{{#if: | | UniProt }} {{#if:|{{{titel}}}|P36551}}{{#if:|Vorlage:Abrufdatum}}</ref><ref>Jassal, D’Eustachio / reactome: Translocation of coproporphyrinogen III from the cytosol to the mitochondrial intermembrane space</ref>

Katalysierte Reaktion

Coproporphyrinogen III + O₂ + 2 H⁺ ⇒
⇒ Protoporphyrinogen IX + 2 CO₂ + 2 H₂O

Coproporphyrinogen III wird zu Protoporphyrinogen IX oxidiert, mit gleichzeitiger Kohlenstoffdioxid-Abspaltung. Es finden hintereinander zwei oxidative Decarboxylierungen statt. Das Enzym benötigt beim Menschen keine Metallionen als Cofaktor.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if:

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    | Vorlage:Cite book/Meldung
  }}</ref>

Weblinks

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• OMA: CPOX Homologe
• Jassal, D’Eustachio / reactome: Conversion of coproporphyrinogen III to protoporphyrinogen IX

Einzelnachweise

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