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Forkhead-Box-Protein P3 – Wikipedia (Deutsch) – Lokale Kopie Zum Inhalt springen

Forkhead-Box-Protein P3

aus Wikipedia, der freien Enzyklopädie
(Weitergeleitet von FOXP3)
{{#if: | {{#if: | {{#if:6106| {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: FOXP3AIID, DIETER, IPEX, JM2, MGC141961, MGC141963, PIDX, XPID3002921891436 | {{#if: FOXP3AIID, DIETER, IPEX, JM2, MGC141961, MGC141963, PIDX, XPID | {{#if: 3002921891436 | {{#if: | {{#if:| {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: | {{#if: Säugetiere<ref>Homologe bei OMA</ref>{{#if: | {{#ifeq: transcription factor | NV ||1}}|}}| {{#if: | {{#ifeq: transcription factor | NV || | style="background:#C3FDB8; color:#000000;" | Homologie-Familie {{#if: Säugetiere<ref>Homologe bei OMA</ref> | | style="background:#C3FDB8; color:#000000;" | Übergeordnetes Taxon {{#if: | | style="background:#C3FDB8; color:#000000;" | Ausnahmen {{#if: {{#if: Maus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe {{#if: ENSG00000049768ENSMUSG00000039521
{{#if: | | Forkhead-Box-Protein P3 }}
[[Datei:|250x200px|{{#if: | | Forkhead-Box-Protein P3 }}]]
Forkhead-Box-Protein P3 }}
Andere Namen

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Vorhandene Strukturdaten: }}

Eigenschaften des menschlichen Proteins

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Masse/Länge Primärstruktur

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Sekundär- bis Quartärstruktur

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Kofaktor

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Präkursor

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Isoformen

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Bezeichner
{{#if:AIID, DIETER, IPEX, JM2, MGC141961, MGC141963, PIDX, XPID | Gen-Namen | Gen-Name}} | Gen-Name(n) }} {{#if:6106 | FOXP3 | FOXP3}}{{#if:AIID, DIETER, IPEX, JM2, MGC141961, MGC141963, PIDX, XPID |, AIID, DIETER, IPEX, JM2, MGC141961, MGC141963, PIDX, XPID}} }}
Externe IDs

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Arzneistoffangaben
ATC-Code 
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DrugBank [1] 
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Wirkstoffklasse 
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Transporter-Klassifikation
TCDB [2] 
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Bezeichnung Transkriptionsfaktor 
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}}

{{#if:|Inhibitorklassifikation|{{#if:|Enzymklassifikationen|Enzymklassifikation}}}}
EC, Kategorie {{#if:| [3]}}{{#if: |, [[]]}} }}
MEROPS {{{Peptidase_fam}}}}}
MEROPS {{{Inhibitor_fam}}}}}
Reaktionsart 
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Substrat 
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Produkte 
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}}

Vorkommen
{{#if: transcription factor|Hovergen}}] transcription factor|Hovergen}}]}} }} }}
Säugetiere<ref>Homologe bei OMA</ref> }}
}}

}}

Mensch Maus
Entrez 
 {{ #if: 50943
50943 }} 
 {{ #if: 20371
20371 }}
style="background:#C3FDB8; color:#202122;" | Ensembl 
    {{ #if: ENSG00000049768
ENSG00000049768 }} 
    {{ #if: ENSMUSG00000039521
ENSMUSG00000039521 }}

} 

 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: Q9BZS1
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q9BZS1}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: Q53Z59
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q53Z59}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_014009NM_054039
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_014009
         | | NM_014009
         | |  }}
      {{ #if: NM_054039
         | | NM_054039
         | |  }}
    |}}
 |-
 {{#if: NP_054728NP_473380
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_054728
         | | NP_054728
         | |  }}
      {{ #if: NP_473380
         | | NP_473380
         | |  }}
    |}}
 |-
 {{#if: X4899384149008232X67432786752193
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: X 
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                | |  }}
            | |  }}
        | |  }}
      {{#if: X 
        | {{#if: 6743278 
            | {{#if: 6752193 
                | |  #if:  |?db=|}}&position=chrX:6743278-6752193 Chr X: {{#expr: 6743278 / 1000000 round 2}} – {{#expr: 6752193 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 50943
    | | 50943
    | |  }}
 {{ #if: 20371
    | | 20371
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 50943 

 {{#if: ENSG00000049768
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000049768 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q9BZS1}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_014009
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_014009 }} 

 {{#if: NP_054728
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_054728 }} 

 {{#if: X 
   | {{#if: 48993841 
       | {{#if: 49008232 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: |?db=|}}&position=chrX:48993841-49008232 Chr X: {{#expr: 48993841 / 1000000 round 2}} – {{#expr: 49008232 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 50943 }} {{#if: Maus 

    | {{#if: 20371ENSMUSG00000039521NM_054039NP_473380X67432786752193Q53Z59 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 20371ENSMUSG00000039521NM_054039NP_473380X67432786752193Q53Z59 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} | {{#if: Maus | | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe 

 |-
 | style="background:#C3FDB8; color:#202122;" |
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Mensch
 | style="background:#C3FDB8; color:#202122; text-align:center;" | Maus
 |-
 | style="background:#C3FDB8; color:#202122;" | Entrez
 {{ #if: 50943
    | | 50943
    | |  }}
 {{ #if: 20371
    | | 20371
    | |  }}
 |-
 {{#if: ENSG00000049768ENSMUSG00000039521
    | | style="background:#C3FDB8; color:#202122;" | Ensembl
    {{ #if: ENSG00000049768
       || ENSG00000049768
       ||  }}
    {{ #if: ENSMUSG00000039521
       || ENSMUSG00000039521
       ||  }}
  |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | UniProt
 {{ #if: Q9BZS1
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q9BZS1}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 {{ #if: Q53Z59
    | | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q53Z59}}{{#if:|Vorlage:Abrufdatum}}
    | |  }}
 |-
 {{#if: NM_014009NM_054039
    | | style="background:#C3FDB8; color:#202122;" | Refseq (mRNA)
      {{ #if: NM_014009
         | | NM_014009
         | |  }}
      {{ #if: NM_054039
         | | NM_054039
         | |  }}
    |}}
 |-
 {{#if: NP_054728NP_473380
    | | style="background:#C3FDB8; color:#202122;" | Refseq (Protein)
      {{ #if: NP_054728
         | | NP_054728
         | |  }}
      {{ #if: NP_473380
         | | NP_473380
         | |  }}
    |}}
 |-
 {{#if: X4899384149008232X67432786752193
    | | style="background:#C3FDB8; color:#202122;" | Genlocus
      {{#if: X 
        | {{#if: 48993841 
            | {{#if: 49008232 
                | |  #if:  |?db=|}}&position=chrX:48993841-49008232 Chr X: {{#expr: 48993841 / 1000000 round 2}} – {{#expr: 49008232 / 1000000 round 2}} Mb 
                | |  }}
            | |  }}
        | |  }}
      {{#if: X 
        | {{#if: 6743278 
            | {{#if: 6752193 
                | |  #if:  |?db=|}}&position=chrX:6743278-6752193 Chr X: {{#expr: 6743278 / 1000000 round 2}} – {{#expr: 6752193 / 1000000 round 2}} Mb 
                | |  }}
           | |  }}
       | |  }}
    |}}
 |-
 | style="background:#C3FDB8; color:#202122;" | PubMed-Suche 
 {{ #if: 50943
    | | 50943
    | |  }}
 {{ #if: 20371
    | | 20371
    | |  }}

| |- | colspan="3" style="background:#90EE90; color:#202122; text-align:center;" | Orthologe (Mensch) |- | style="background:#C3FDB8; color:#202122;" | Entrez | colspan="2" | 50943 

 {{#if: ENSG00000049768
    | |-

| style="background:#C3FDB8; color:#202122;" | Ensembl | colspan="2" | ENSG00000049768 }} |- | style="background:#C3FDB8; color:#202122;" | UniProt | colspan="2" | {{#if: kurz| | UniProt }} {{#if:|{{{titel}}}|Q9BZS1}}{{#if:|Vorlage:Abrufdatum}} 

 {{#if: NM_014009
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (mRNA) | colspan="2" | NM_014009 }} 

 {{#if: NP_054728
    | |-

| style="background:#C3FDB8; color:#202122;" | Refseq (Protein) | colspan="2" | NP_054728 }} 

 {{#if: X 
   | {{#if: 48993841 
       | {{#if: 49008232 
           | |-

| style="background:#C3FDB8; color:#202122;" | Genlocus | colspan="2" | #if: |?db=|}}&position=chrX:48993841-49008232 Chr X: {{#expr: 48993841 / 1000000 round 2}} – {{#expr: 49008232 / 1000000 round 2}} Mb 

           |  }}
       |  }}
   |  }}

|- | style="background:#C3FDB8; color:#202122;" | PubMed-Suche | colspan="2" | 50943 }} {{#if: Maus 

    | {{#if: 20371ENSMUSG00000039521NM_054039NP_473380X67432786752193Q53Z59 
        |
        |  Spezies2= ist definiert, es sind jedoch keine weiteren Angaben zu Spezies2 vorhanden.{{#ifeq:0|0| }} }}
    | {{#if: 20371ENSMUSG00000039521NM_054039NP_473380X67432786752193Q53Z59 
        |  Es sind Angaben zu Spezies2 vorhanden, Spezies2= ist jedoch nicht definiert.{{#ifeq:0|0| }}
        |}}

}} }}

|}{{#if:||}}

Das Forkhead-Box-Protein P3 (FoxP3), auch Scurfin<ref name="PMID12874208">D. J. Kasprowicz, P. S. Smallwood u. a.: Scurfin (FoxP3) controls T-dependent immune responses in vivo through regulation of CD4+ T cell effector function. In: Journal of Immunology. Band 171, Nummer 3, August 2003, S. 1216–1223, PMID 12874208.</ref> genannt, ist ein Protein, das im Zellkern von Säugetieren vorkommt. Es handelt sich um einen Transkriptionsfaktor, der an die DNA (Desoxyribonukleinsäure) bindet und damit die Expression von Proteinen stimuliert, die in den regulatorischen T-Zellen des Immunsystems gebraucht werden. Da FoxP3 spezifisch für native und peripher entstandene regulatorische T-Zellen ist, kann man diese damit nachweisen. FoxP3 ist weiterhin ein essentieller Transkriptionsfaktor für regulatorische T-Zellen, da gezeigt wurde, dass nach genetischer Veränderung von Mäusen (FoxP3-Knockout) diese keine regulatorischen T-Zellen bilden. Homozygote FoxP3-Knockout-Mäuse, bei denen FoxP3 permanent in allen Zellen mutiert wurde, sind nicht vermehrungsfähig, wohingegen die heterozygoten Tiere lediglich vermindert vermehrungsfähig sind.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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Datei:34 Nobel Prize FOXP3 Hegasy v03A4 DE-01.png
Nobelpreis in Physiologie oder Medizin 2025: FoxP3+ Treg Zellen in der Immuntoleranz.

Beim Menschen führen bestimmte Mutationen im FOXP3-Gen zu einer polyendokrinen Autoimmunerkrankung. Sie ist dadurch zu erklären, dass die regulatorischen T-Zellen die Autoimmunreaktionen nicht unterdrücken können. Der Transkriptionsfaktor FoxP3 stammt aus der Familie der Forkhead-Box-Proteine.<ref>{{#if: | | UniProt }} {{#if:|{{{titel}}}|Q9BZS1}}{{#if:|Vorlage:Abrufdatum}}</ref>

Regulatorische T-Zellen spielen eine Rolle bei Autoimmunerkrankungen wie beispielsweise Rheumatoide Arthritis und Lupus erythematodes. Die Ausscheidung von FoxP3-mRNA ist bei solchen Patienten erhöht, wie auch generell nach Nierentransplantation. FoxP3-Zufuhr führte in einer Studie an Mäusen zur Verhinderung von Krebs-Metastasen.<ref>{{#invoke:Vorlage:Literatur|f}}{{#if: 

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  }}</ref><ref name="PMID23396208">H. Nie, Y. Zheng u. a.: Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-? in rheumatoid arthritis. In: Nature Medicine. Band 19, Nummer 3, März 2013, S. 322–328, {{#invoke:URIutil|{{#ifeq:1|1|linkISSN|targetISSN}}|1546-170X|0}}{{#ifeq:1|0|[!]

}}{{#ifeq:0|1 

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}}{{#ifeq:0|0 

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}}. {{#invoke:Vorlage:Handle|f|scheme=doi|class=plainlinks|parProblem=Problem|errCat=Wikipedia:Vorlagenfehler/Parameter:DOI|errClasses=error editoronly|errHide=1|errNS=0 4 10 100}}. PMID 23396208. </ref>

Einzelnachweise

<references />

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